The water is bitter and undrinkable, being largely impregnated with carbonate and sulphate of soda with some borax.
Thus Yahweh smites the river so that the fish die and render the water undrinkable.
The wine becomes turbid and acquires a peculiarly bitter sweet taste, and if the disease goes further becomes quite undrinkable.
Spitfire Ale is not undrinkable, but it is nothing special.
When the acidity is too high, the wine usually becomes undrinkable.