The long-continued incitement to catabolism of the waking day thus of itself predisposes the nerve cells towards rebound into the opposite phase; the increased catabolism due to the day's stimuli induces increase of anabolism, and though recuperation goes on to a large extent during the day itself, the recuperative process is slower than, and lags behind, the disintegrative.
The profound lack of circulating a1-antitrypsin predisposes the Z a1-antitrypsin homozygote to early onset emphysema.
A study looking at severe and disfiguring mucocutaneous leishmaniasis has identified a single gene which predisposes to this particular type of disease.
For familial cases, no single gene has been identified that strongly predisposes a person to MS.
In addition, subclinical deficiencies often predisposes animals to other diseases.