The cause of rupture was the attack on Pontic territory by Nicomedes at the instigation of the Romans.
His daughter Berenice meanwhile reigned in Alexandria, a husband being found for her in the Pontic prince Archelaus.
Of the Pontic rulers two are most famous.
But it was also frequently used to denote (in whole or part) that portion of the old Mithradatic kingdom which lay between the Halys (roughly) and the borders of Colchis, Lesser Armenia, Cappadocia and Galatia - the region properly designated by the title "Cappadocia towards the Pontus," which was always the nucleus of the Pontic kingdom.
But presently the process of annexation began and the Pontic districts were gradually incorporated in the empire, each being attached to the province of Galatia, then the centre of Roman forward policy.