Left to himself Innocent again had to flee, this time to Pisa.
From 1489 to 1491 he studied theology and canon law at Pisa under Filippo Decio and Bartolomeo Sozzini.
In the continual struggles between Pisa and Genoa some of these princes took the side of the latter.
The Arno, which has its source in the Monte Falterona, one of the most elevated summits of the main chain of the Tuscan Apennines, flows nearly south till in the neighborhood of Arezzo it turns abruptly north-west, and pursues that course as far as Pontassieve, where it again makes a sudden bend to the west, and pursues a westerly course thence to the sea, passing through Florence and Pisa.
Cesare, then a youth of sixteen and a student at Pisa, was made archbishop of Valencia, his nephew Giovanni received a cardinal's hat, and for the duke of Gandia and Giuffre the pope proposed to carve fiefs out of the papal states and the kingdom of Naples.