The geography of Central Italy is almost wholly determined by the Apennines, which traverse it in a direction from about north-north-east to south-south-west, almost precisely parallel to that of the coast of the Adriatic from Rimini to Pescara.
The most celebrated captains of these wars were present on either side - under Gaston de Foix were Bayard, Yves d'Allegre, La Palisse; and under Cardona the Spanish viceroy of Naples, Pedro Navarro the great engineer, and Pescara the originator of the Spanish tactical system.
The left wing was composed of the papal contingent, 6000 infantry and 800 gendarmes under Fabrizio Colonna; the centre, of half the Spanish contingent, 4000 infantry and 600 lancers under the viceroy; the right, of 1000 light horse under Pescara.
But after three hours, Pescara's light horse having meantime been driven in by the superior light horse of the enemy, the artillery-loving duke of Ferrara conceived the brilliant plan of taking his mobile field-guns to the extreme right of the enemy.
From Popoli the road followed the valley of the Aternus to its mouth, and there joined the coast-road at Pescara.