The boundary with Paraguay was definitely settled in 187 2.
Apart from such a peculiar development as the rise, formation and fall of the Jesuit missions in Paraguay, there was growth and change.
For the details of the struggle the reader must refer to the articles Argentina, Bolivia, Chile, Colombia, Ecuador, Panama, Peru, Paraguay, Uruguay, Venezuela.
When it was remembered, too, that they had decided, at a council held at Lima, that it was inexpedient to impose any act of Christian devotion except baptism on the South American converts, without the greatest precautions, on the ground of intellectual difficulties, it is not wonderful that this doubt was not satisfactorily cleared up, notably in face of the charges brought against the Society by Bernardin de Cardonas, bishop of Paraguay, and the saintly Juan de Palafox, bishop of Angelopolis in Mexico.
In 1753 Spain and Portugal exchanged certain American provinces with each other, which involved a transfer of sovereign rights over Paraguay; but it was also provided that the populations should severally migrate also, that the subjects of each crown might remain the same as before.