With the hit television show Grey's Anatomy and the 2007 summer box office hit Knocked Up in her arsenal, Katherine Heigl is definitely considered one of the "It Girls" of the moment.
Hathaway turned down the lead in 2007's Knocked Up because the movie portrayed a graphic scene of a woman giving birth.
It was Rogen's role as loveable loser Ben Stone in Knocked Up that put him on the map as a leading man -- albeit a bit unconventional.
Her first breakout film, the one that put her rom-com star power status on lock, was Knocked Up with Seth Rogen.
In a detraction from her normal foot-in-mouth barbs regarding movies like Knocked Up and shows like Grey's Anatomy, that made her career, Heigl's comments about her early Grey's departure were rather subdued.
