Game-over Definition

(video games) A message that appears on the screen of a computer or video game when all of the player's lives have been lost and the game must be started again from a checkpoint, the time runs out, or save point, or when the game has been successfully completed.

Wiktionary
(by extension) The end of some ongoing situation due to either failure or success.
If your wife finds out about us, it's game over!
Wiktionary

Other Word Forms of Game-over

Noun

Singular:
game-over
Plural:
game overs

Origin of Game-over

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game-over