Cranial nerve palsies of the third, fourth and sixth cranial nerve palsies of the third, fourth and sixth cranial nerves may occur, affecting extraocular motility.
The prognosis is poorer if the cancer has spread beyond the eye (extraocular).
An extraocular retinoblastoma could involve only the tissues around the eye or could result from the spread of cancer to the brain or other parts of the body.
There is no proven effective therapy for the treatment of extraocular retinoblastomas.
Those with extraocular retinoblastoma have less than a 10 percent chance of disease-free survival for the same amount of time.