Probably the bar of language was the most prominent cause of estrangement.
No doubt there must have been some kind of foundation for Pirkheimer's charges; and it is to be noted that neither in Darer's early correspondence with this intimate friend, nor anywhere in his journals, does he use any expressions of tenderness or affection for his wife, only speaking of her as his housemate and of her helping in the sale of his prints,&c. That he took her with him on his journey to the Netherlands shows at any rate that there can have been no acute estrangement.
The aftermath of Fremont's filibustering acts, followed as they were by wholly needless hostilities and by some injustice then and later in the attitude of Americans toward the natives, was a growing misunderstanding, and estrangement regrettable in Californian history.
At the same time he was no longer on the former friendly terms with Essex, a certain estrangement 1 Spedding, Letters and Life, i.
In 1812 he was aided by Cuvier to obtain the chair of anatomy and zoology in the Faculty of Sciences at Paris, but subsequently an estrangement grew up between the two men and ended in open enmity.