During Somerset's protectorate he entered public life and was made a secretary of state, being sent on an important diplomatic mission to Brussels.
It was in this same year that he received the singular diplomatic mission to Frederick which nobody seems to have taken seriously, and after his return the oscillation between Brussels, Cirey and Paris was resumed.
During his diplomatic mission to France he had incurred blame for remaining at the opera while the Pretender was present,3 and according to the Mackintosh transcripts he had several secret interviews with him.
On reaching Italy Czartoryski found that the monarch to whom he was accredited was a king without a kingdom, so that the outcome of his first diplomatic mission was a pleasant tour through Italy to Naples, the acquisition of the Italian language, and a careful exploration of the antiquities of Rome.
We first hear of him in 1661 on a diplomatic mission from the Don Cossacks to the Kalmuck Tatars, and in the same year we meet him on a pilgrimage of a thousand miles to the great Solovetsky monastery on the White Sea "for the benefit of his soul."