Cleopatra's daughter by Antony (Cleopatra Selene) was married in 25 to Juba II.
He killed Berenice and, dying in 51, bequeathed the kingdom to his eldest son, aged ten years, who was to take as wife his sister Cleopatra, aged seventeen.
An impostor, who claimed to be a son of Antiochus Epiphanes, Alexander Balas (reigned 150-145), was installed as king by Ptolemy Philometor and given Ptolemy's daughter Cleopatra to wife, but Alexander proved to be dissolute and incapable, and when Demetrius, the son of Demetrius I., was brought back to Syria by Cretan condottieri, Ptolemy transferred his support and Cleopatra to the rightful heir.
The newly born son of Philip by Cleopatra, and Alexander's cousin Amyntas, were put to death, and Alexander took up the interrupted work of his father.
Her efforts were at first successful, but in 36 Antony left for the Parthian War and renewed his intrigue with Cleopatra.