His eldest son, Archibald Napier of Edinbellie, the fourth of Merchiston, belonged to the household of James IV.
His eldest son was Archibald, seventh of Merchiston, and the father of John Napier, the subject of this article.
In 1549 Archibald Napier, at the early age of about fifteen, married Janet, daughter of Francis Bothwell, and in the following year John Napier was born.
In 1582 Sir Archibald was appointed master of the mint in Scotland, with the sole charge of superintending the mines and minerals within the realm, and this office he held till his death in 1608.
About the end of the year 1579 his wife died, leaving him one son, Archibald (who in 1627 was raised to the peerage by the title of Lord Napier), and one daughter, Jane.