It was captured in 191 by the Romans, but restored to the Aetolian League until 146.
At this point Aratus appealed to Sparta to help the Achaeans in repelling an expected Aetolian attack, and Agis was sent to the Isthmus at the head of an army.
It was, however, recovered for Ptolemy by the Aetolian Scopas.
During the 3rd century it passed into the power of Macedonia and of the Aetolian League, to which in 196 it was definitely annexed.
The name of the island, Ortygia (6prv, a quail), has, again, been held to point to the possible existence of an Aetolian settlement on the island before Archias came.