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homology Definition

ho·mol·ogy (hō mälə jē, hə-)

noun pl. -·gies

  1. the quality or state of being homologous
  2. a homologous correspondence or relationship, as of animal organs, chemical compounds, etc.

Etymology: LL homologia < Gr: see homo- & -logy

homology Usage Examples

Converse of object

  • show: This kinase domain shows approximately 84 % homology with the insulin receptor.
  • share: The genes for hK2 and PSA are expressed predominately in the prostate, are transcriptionally up-regulated by androgens, and share 78 % homology.
  • have: A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.
  • use: Projector thus uses sequence homology directly at DNA level and takes the conservation of gene structures between related genes explicitly into account.

Adjective modifier

  • structural: ATP-dependent ion pumps are grouped into classes, based on transport mechanism as well as genetic and structural homology.
  • significant: Neither primer had significant sequence homology with any other DNA component of BBTV.
  • overall: The full-length sequence exhibits little overall homology to any other known protein at either the nucleotide or the amino acid level.
  • high: This is especially the case after building by homology from a structure with a high homology, or after making a few point mutants.
  • great: Its amino acid sequence shows much greater homology to consensus sequences derived from protein serine/threonine kinases than to the consensus for protein tyrosine kinases.
  • low: Similar binding sites in terms of surface shape and properties, but which have low homology with the reference structure, may also exist.

Modifies a noun

  • modeling: Results of homology modeling are more likely to be reliable than are results derived purely from theory ( ab initio modeling ).
  • domain: These proteins are type II integral membrane proteins composed of multiple spectrin repeats with N-terminal paired calponin homology domains.
  • recognition: FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties.
  • search: These matrices appear to be the best available for carrying out data base similarity ( homology searches ).
  • decomposition: The main objective of this project was to develop the long sought for " subgroup homology decomposition for p compact groups " .

Noun used with modifier

  • pleckstrin: Many signal proteins bind via lipid anchors and/or pleckstrin homology domains to the cytosolic surface of the plasma membrane.
  • sequence: The database is searchable by sequence name, sequence homology or direct SQL query.
  • protein: Block Searcher, Get Blocks and Block Maker are aids to detection and verification of protein sequence homology.
  • %: This kinase domain shows approximately 84 % homology with the insulin receptor.
  • share: Clues to the normal function of MLL in mammalian haematopoiesis have come from the identification of domains that share homology with other known proteins.